In multivariate analysis, having HIV-positive partners (adjusted HR (AHR) =3.756; 95%CI 1.180 to 11.955) and developing a rapid plasma reagin titre of 4 or greater (AHR=9.978; 95% CI 1.550 to 64.233) were significantly associated with HCV seroconversion.
Conclusions An increasing trend of recent HCV infection occurs among individuals seeking VCT services in Taiwan.
The incidence rate of syphilis also increased from 11. PYFU in 2006–2009 to 31. PYFU in 2012–2013 (figure 1); the rates were significantly higher in HCV seroconverters than non-seroconverters during the three corresponding study periods.
In multivariate analysis, HCV seroconverters were more likely to have HIV-positive partners (adjusted HR (AHR) 3.756; 95% CI 1.180 to 11.955) and a RPR titre of four or greater (AHR 9.978; 95% CI 1.550 to 64.233) than HCV non-seroconverters (table 2).
Recent HCV seroconversion was defined as the first positive HCV antibody that was detected within 1 year after the previous negative HCV antibody.
After completion of integrated pretesting and post-testing counselling, a blood sample was obtained for testing for HIV, syphilis and viral hepatitis.25In this study, all clients who sought VCT services between May 2006 and December 2013 were included, and clients using the same code who sought VCT services more than two times with an interval of 6 months or longer were eligible for inclusion to estimate the incidence rate of HCV seroconversion.
IDUs and clients who sought VCT services only once or with repeat tests performed at an interval of less than 6 months were excluded.
Results The overall HCV seroprevalence at baseline was 0.3%.
Of 2150 clients testing negative for anti-HCV antibody at baseline with a total of 5074.99 person-years of follow-up (PYFU), 17 (0.8%) developed HCV seroconversion, leading to an overall incidence rate of 3. PYFU (95% CI 1.76 to 4.94), which increased from 2.28 (95% CI 0.05 to 4.51) in 2006–2009, to 3.33 (95% CI 0.86 to 5.80) in 2010 to 2011 and 4. PYFU (95% CI 0.99 to 8.99) in 2012–2013; the incidence of early syphilis increased from 11.91 to 13.28 and 31. PYFU in the three corresponding periods.